The aging of the skin is an inevitable physiological process that results in the loss of its natural elasticity and the appearance of wrinkles. PROTAI︎® stands out for its outstanding characteristics, possessing several key functions, including strengthening antioxidant activity, promoting skin cell proliferation, superior wound repair and healing efficacy, while also providing excellent moisturizing effects. Furthermore, PROTAI︎® has been proven to enhance skin elasticity, offering comprehensive care for the skin and effectively delaying skin aging.
The skin, serving as the body's natural external defense barrier, effectively resists external environmental threats, providing a certain level of protection.
However, this also makes it difficult for the nutritional components in cosmetics to penetrate the surface of the skin. Nutrients must pass through the stratum corneum cell membrane to enter the dermis layer.
Moreover, large molecules and lipid-soluble substances can only be absorbed in very small amounts through pores and sweat ducts.
Generally speaking, most of the cosmetics we use only stay on the surface of the skin and cannot effectively penetrate into the dermis layer.
However, biologically active beauty peptides have the ability to traverse the gaps in the stratum corneum, entering the dermis layer and thereby exerting their effects.
H2DCF-DA exhibits high sensitivity to hydrogen peroxide (H2O2) and can be applied to detect intracellular production of reactive oxygen species (ROS).
By measuring the intensity of DCF fluorescence, we can assess the level of ROS generation within the cells.
During the cultivation period, samples from the PROTAI™ series were added to the culture medium (10 μl) and cultured for 1 hour under light-avoiding conditions at 37°C.
After cultivation, cells were washed with PBS, and then the fluorescence signal was determined using a fluorescence spectrophotometer (excitation wavelength/emission wavelength: 485/538 nm). All data are the averages of three repeated experiments.
After incorporating PROTAI™, the reduction in ROS (Reactive Oxygen Species) free radicals is 15%.
There are various reasons for the loss of skin elasticity, including aging, prolonged periods of staying awake, improper sleep patterns, intense exposure to sunlight, exaggerated facial expressions, and even improper massage techniques.
These factors can lead to damage to internal collagen and elastin fibers, resulting in a decrease in fiber quantity and a slowdown in regenerative capabilities. Simultaneously, the ability to support the epidermis weakens, manifesting externally as loss of skin elasticity, and the appearance of sagging, fine lines, wrinkles, and other phenomena.
The areas around the eyes, nostrils, and lips are particularly prone to showing signs of skin losing elasticity and exhibiting sagging.
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After testing with PROTAI™, there is a 22% increase in moisturization and an 8% increase in skin elasticity.
This indicates that PROTAI™ has moisturizing and elasticity-restoring effects.
PROTAI™ is a short-chain peptide combination with various skin-protective functions, including promoting skin regeneration, wound repair and healing, moisturizing, and increasing skin elasticity.
Through experimental validation, it has been shown to effectively promote the migration of epithelial cells, thereby facilitating wound repair and enhancing skin moisture and elasticity.
With the addition of PROTAI™, there was a significant increase in migration repair,
ranging from 77 - 100 %, demonstrating pronounced healing effects.
The single-molecule membrane of HaCaT epithelial cells was employed for the detection of wounds caused by incisions. Pre-treatment images were obtained before the application of PROTAI™. After 18 hours of cell incubation, images were captured following fixation and post-processing.
By comparing and analyzing the images before and after through microscopic imaging, the central gap area was identified.
After 18 hours of migration repair testing, samples treated with the sequence-specific peptide of PROTAI™
showed a reduction of 3.4 ± 1.1.1 in the blank area, representing a decrease of 77%.
Following treatment with a high concentration of PROTAI™, the blank area decreased by 0.7 ± 0.33, reflecting a reduction of 95%.
In summary, based on these results, PROTAI™ demonstrates outstanding effects in inducing epithelial cell migration and promoting skin repair.
| Patent Location | Certificate Number | Name Of The Patent |
|---|---|---|
| TAIWAN | I693941 | Short-chain peptide combination and its application in skin protection. |
| CHINA | ZL 2019 1 0114492.X | Short-chain peptide combination and its application in skin protection. |
According to the survey, the target age group in the skincare market is primarily concentrated in the mature demographic aged 40 and above, especially those in the 40-49 age range who are already in the workforce and have a high demand for their outward appearance.
Concerning skincare, this group is most interested in issues such as sensitive skin, oil secretion, uneven skin tone, signs of aging, and loss of elasticity.
Research indicates that they are most likely to perceive these changes during "seasonal transitions," and in skincare, the most popular element among women is "hydration."
To meet this demand, we have collaborated with Leylan International Trading Co. to launch the Marstani series of peptide-infused face masks and skincare serums, especially featuring PROTAI™.
These products not only incorporate carefully crafted formulations but also encompass superior effects in promoting skin repair, increasing moisture, and enhancing elasticity.
Designed specifically for the mature demographic, this face mask not only represents a tailored solution but also vividly showcases the results of our research with PROTAI™, providing you with an age-defying skincare experience.
